There's so much to do while you are down there; those two days will go by in a flash! Remember to pace yourself while riding.
Are you riding down there or trailering the bike? Going solo or with a group of fellow riders?
Visit the Killboy website 1st.
Then continue to read several write-ups about the area using Google and glean info from a few different motorcycling message boards. Jot down some of the places down there that sound interesting to YOU and YOUR group and you've got yourself a personalized guide/outline to keep you on track.
Be careful of the "tourist traps" in and around the general area (think Pigeon Forge/Gatlinburg area - no offense to those who enjoy those sorts of things LOL). You'll have plenty of photo-ops during riding breaks for great views of the Smoky Mountains.
Here's a few highlights that our group touched on while visiting the area last summer:
Rented a cabin in Wears Valley TN
Rode the Foothills Parkway, Tail of the Dragon, Cherohala Skyway
Some in our group visited Clingman's Dome
Deals Gap Motorcycle Resort (souveniers)
While riding we stopped for snacks at the Thunder Mountain General Store & Deli in Robbinsville NC ( Thunder Mountain General Store and Deli
At the end of one of our rides we ate dinner at a place called Kram Bonez BBQ in Tellico Plains TN
Hope I didn't throw too much at ya, the trip is what you make of it - enjoy it & ride safely !